Codeine phosphate is a narcotic pain-reliever and cough suppressant similar to morphine and hydrocodone. Moreover, a small amount of codeine is converted to morphine in the body. The precise mechanism of action of codeine is not known; however, like morphine, codeine binds to receptors in the brain (opioid receptors) that are important for transmitting the sensation of pain throughout the body and brain. Codeine increases tolerance to pain, decreasing discomfort, but the pain still is apparent to the patient. In addition to reducing pain, codeine also causes sedation drowsiness and depresses breathing. Codeine frequently is combined with acetaminophen (Tylenol) or aspirin for more effective pain relief. The FDA approved codeine in 1950.
WHAT ARE THE USES FOR CODEINE?
Codeine is used for the relief of mild to moderately severe pain and for suppressing cough.
WHAT ARE THE SIDE EFFECTS OF CODEINE PHOSPHATE?
- The most frequent side effects of codeine include:
- Shortness of breath
- Allergic reactions
- Abdominal pain
- Rash, also
Serious side effects of codeine include:
- Life-threatening respiratory depression
- Severe low blood pressure
- Adrenal insufficiency, also
- Accidental ingestion of codeine can result in fatal overdose